Endocrine Abstracts

Introduction: Giant prolactinomas (diameter >4 cm) account for less than 5% of all prolactinomas and are usually associated with markedly elevated prolactin (PRL) levels. Despite their benign nature, these tumors can be invasive, potentially leading to mass effect symptoms in affected patients.Case Report: We report a case of a 40-year-old male admitted to the emergency department with a one-week history of headaches, right palpebral edema, and ptosi...

Mice with isolated GH deficiency (IGHD) due to GHRH receptor mutations live longer than their normal siblings with an extended healthspan, i.e., the period of life free from disabilities. Human IGHD individuals due to a mutation in the GHRH receptor gene from Itabaianinha, Brazil, has a normal lifespan with an extended healthspan (1). Our hypothesis is that their aging is accompanied by a delayed cognitive decline. Accordingly, we used the Literacy Independent Cognitive Assess...

Population aging has become a universal worldwide phenomenon. Developing countries (such as Portuguese-speaking countries, with a high rate of illiteracy) will see the greatest increase in the absolute number of elderly people, and dementia disorders will pose enormous challenges to public health in these countries. Although the decline in GH secretion with age has been associated with deleterious conditions of aging, our understanding is the opposite, that the decline in GH s...

Introduction: Low-grade pituitary gliomas are extremely rare neoplasms, originating from the pituicytes of the posterior pituitary or infundibulum. The incidence of these tumors increases with age and peaks in the seventh decade of life. Gliomas are primary brain tumors of the supporting glial cells of the central nervous system, which derive from neuroglial stem cells or progenitor cells. They are responsible for nearly 30% of all primary brain tumors and 80% of all malignant...

Aim: Dose corrected for thyroid gland size is one of the methods used to determine radioactive iodine (RAI) activity for patients with Graves disease (GD). This study was aimed to investigate the real-world success rate of this method and the predictors of success after first treatment.Methods: This is a retrospective study of 80 patients with GD treated between 2014 and 2020 in a tertiary referral hospital in Almada, Portugal. The successful group was d...

Introduction: Primary hypobetalipoproteinemia corresponds to a series of congenital disorders that have a variable incidence from 3.2% to less than 1 in 1 million, depending on the type of genetic mutation. The diseases that comprise it occur due to different types of mutations in genes that will encode important proteins at different stages of lipid metabolism. Individuals with determinant mutations of severe phenotypes, such as Bassen-Kornzweig syndrome, as known as Abetalip...

Introduction: Treatment of differentiated thyroid carcinoma (DTC) remains a challenge in the setting of locally advanced or metastatic disease refractory to radiodine (RAI) therapy. SELECT trial demonstrated that Lenvatinib improved progression free survival (PFS) comparing to placebo.Objective: Our aim is to report the efficacy and safety of lenvatinib in our population with aggressive DTC.Methods: We retrospectively reviewed the ...

Objectives: The angiotensin-converting enzyme (ACE1) gene is one of the most studied genes in the pathogenesis of type II diabetes (T2DM) and cardiovascular disease. However, in the context of exerciSemodels in T2DM, they are not yet fully understood. We intended to characterize the genetic profile of individuals with T2DM from an inter-individual point of view using prognostic markers and cardiovascular risk. On the other hand, relate it with the profile obtained wit...

Background: Immune checkpoint inhibitors (ICI) are an innovative oncologic therapy used in several types of solid and hematological neoplasms. This treatment enables the antitumoral immune system response and results in significant improvement of clinical outcomes and survival rate. However, endocrine related adverse effects (ERAE) have been related, with thyroid and pituitary dysfunction being the most common endocrine diseases described. An association between the surge of e...

Background and objective: According to recent studies, endocrine societies have modified the treatment criteria of subclinical gestational hypothyroidism, increasing TSH upper-limit value commonly set at 2.5 μU/ml to a new threshold set at 4 μU/ml. This change in criteria has responded to numerous studies which seem to indicate that the obstetrical complications do not generally increase despite this variation of the threshold TSH value. A further discussion lays now...